Spore formation skin#

1, 2 Case PresentationĪ 22-year-old male cook was admitted to the Dermatology Department of the Second Affiliated Hospital of Kunming Medical University with a 15-day history of fever as well as escharotic and purpuric skin lesions on his lower limbs. In addition, they may also be associated with Gram-negative bacilli, staphylococcus, streptococcus, rickettsia, and measles. Meningococcus and varicella virus are the two most common bacteria and trigger viruses. (1) Neonatal PF is related to the genetic deficiency of natural anticoagulant proteins C and S (2) idiopathic or chronic PF occurs after the incubation period of various viral infections and (3) the most classic and common form of this disease, called acute infectious PF (AIPF), occurs when it is superimposed on bacterial infections this kind of PF is related mainly to acquired protein C deficiency. The pathogenesis of the disease has recently been classified according to the following three types of trigger mechanisms. It progresses rapidly, with vascular collapse and systemic disseminated intravascular coagulation (DIC). Purpura fulminans (PF) is a rare syndrome of intravascular thrombosis and skin hemorrhagic infarction and necrosis that usually occurs in children. Keywords: acute infectious purpura fulminans, Klebsiella pneumoniae, human herpesvirus type 5, disseminated intravascular coagulation, multiple organ and system failures Clinicians should be aware of this for early diagnosis and treatment.

After successful treatment by the departments of Dermatology, Emergency Critical Care Medicine, and the Intensive Care Unit, the patient was discharged after 67 days of hospitalization.Ĭonclusion: Adults with acquired protein C and/or S deficiency states, including certain bacterial and viral infections, who drink alcohol and take varieties of non-steroidal anti-inflammatory analgesics at the same time, may develop acute infectious PF. The histopathological examination of the skin lesions revealed pathological features consistent with PF. In addition, human herpesvirus type 5 was detected. The results of the high-throughput genetic testing of the pathogenic microorganism DNA were consistent. The blood, sputum, and secretions under the skin lesions were cultured and were positive for Klebsiella pneumoniae. The laboratory tests showed signs of sepsis, thrombocytopenia, an abnormal decrease in protein C and antithrombin III, DIC, multiple organ and system failures, gastric varices, and gastrointestinal hemorrhage. The ultrasound and computed tomography scans revealed infections in the skin wounds as well as venous microthrombosis and thrombosis in multiple intracranial and pulmonary vessels. This may progress rapidly to multiorgan failure caused by the thrombotic occlusion of small- and medium-sized blood vessels.Ĭase Report: This article presents the case of a 22-year-old male with fever as well as necrotic and purpuric skin lesions. In PF, the skin necrosis and DIC are secondary to protein C deficiency. 374 of Dian-Mian Avenue, Wu-Hua District, Kunming, 650101, People’s Republic of China, Tel +2212, Fax +4416, Email īackground: Purpura fulminans (PF), a rare, life-threatening disorder, is a hematological emergency in which there is skin necrosis, disseminated intravascular coagulation (DIC), and protein C deficiency. Xiao-Lan Li, 1 Chun-Yan Luan, 1 Ying-Jun Fan, 2 Xiao-Ying Lin, 1 Dong Jiang, 1 Mei-Xian Su, 3 Gang Wang, 4 Xu Yang 5ġDepartment of Dermatology, The Second Affiliated Hospital of Kunming Medical University, Kunming, 650101, People’s Republic of China 2Department of Rheumatology, The Second Affiliated Hospital of Kunming Medical University, Kunming, 650101, People’s Republic of China 3Department of Emergency Critical Care Medicine, The Second Affiliated Hospital of Kunming Medical University, Kunming, 650101, People’s Republic of China 4Department of Intensive Care Unit, The Second Affiliated Hospital of Kunming Medical University, Kunming, 650101, People’s Republic of China 5Laboratory Bacteria Room, The Second Affiliated Hospital of Kunming Medical University, Kunming, 650101, People’s Republic of ChinaĬorrespondence: Xiao-Lan Li, Department of Dermatology, The Second Affiliated Hospital of Kunming Medical University, No.

Spore formation